IMPROVED IMPLANT MATERIALS, METHODS OF TREATING THE SURFACE OF IMPLANTS WITH MICROVASCULAR ENDOTHELIAL CELLS, AND THE TREATED IMPLANTS THEMSELVES

• Main Authors: WILLIAMS, STUART, K, JARRELL, BRUCE, E
• Format: Patent
• Language: English; French
• Published: 14.04.1994
• Edition: 5
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; PROSTHESES; SPIRITS; TREATMENT OR PROTECTION OF EYES OR EARS; VINEGAR; WINE

Novel implant materials having porosity are provided by the present invention. Novel methods for treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient are also provided comprising obtaining human microvascular fat tissue, homogenizing the fat tissue to provide a cellular slurry, and applying the cellular slurry onto said implant to provide at least 50 % confluence of said cells on the surface and/or within the pores of the implant. Cette invention concerne de nouveaux matériaux d'implants poreux ainsi que de nouveaux procédés de traitement d'un implant synthétique ou naturel tel qu'une greffe vasculaire, destiné à être implanté chez un patient, selon lesquels on recueille des tissus gras de vaisseaux de petit calibre, on homogénéise les tissus gras pour obtenir une pâte cellulaire et on applique cette pâte cellulaire sur ledit implant de sorte qu'au moins 50 % desdites cellules confluent sur la surface et/ou à l'intérieur des pores de l'implant.