(-)-RITODRINE

• Main Authors: FUKUDA, YOSHIMASA, NIIZATO, TETSUTAROU, YAMAZAKI, NAOKI, SHIBAZAKI, YOSHIAKI
• Format: Patent
• Language: English; French; Japanese
• Published: 20.01.1994
• Edition: 5
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

(-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-[2-(p-hydroxyphenyl)ethylamino]-1-pr opanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (+/-)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea. (-)-Ritodrine, i.e. (-)-erythro-1-(p-hydroxyphenyl)-2-(2-(p-hydroxyphenyl)ethylamino)-1-propanol, which is substantially free from the (+)-isomer, or a salt thereof. This compound has a potent effect of inhibiting uterine contraction as compared with (+-)-ritodrine and (+)-ritodrine and a toxicity comparable to those of the other ritodrines, and hence is usable as a highly safe remedy for threatened premature birth and abortion and a remedy for dysmenorrhea. (-)-ritodrine, c'est-à-dire le (-)-érythro-1-(p-hydroxyphényl)-2-[2-(p-hydroxyphényl)éthylamino]-1-propanol, sensiblement exempt du (+)-isomère, ou d'un sel de celui-ci. Ce composé présente un effet d'inhibition de la contraction utérine plus puissant que celui de la (U)-ritodrine et de la (+)-ritodrine, ainsi qu'une toxicité comparable à celle des autres ritodrines. Il est donc utilisable comme remède très sûr en cas de risque d'une naissance avant-terme ou d'un avortement, et comme remède contre la dysménorrhée.