MEASUREMENT OF PLATELET ACTIVITIES

• Main Authors: HEMKER, HENDRIK, C, WAGENVOORD, ROBERT, J
• Format: Patent
• Language: English; French
• Published: 09.12.1993
• Edition: 5
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

Methods are provided for measuring the procoagulant activity of platelets in blood by means of a chromogenic assay which is specific for procoagulant phospholipids. These methods include the determination of the resting activity and/or excitability of platelets, which determines the threshold at which activating clotting factors (circulating in blood) are dangerous. Also methods are provided for screening drugs for their potential inhibitory effect on the activation of platelets. L'invention concerne des procédés de mesure de l'activité procoagulante de plaquettes du sang au moyen d'un dosage chromogène spécifique aux phospholipides procoagulants. Lesdits procédés comprennent la détermination de l'activité de repos et/ou de l'excitabilité des plaquettes, ce qui détermine le seuil à partir duquel des facteurs d'activation de la coagulation (circulant dans le sang) sont dangereux. L'invention concerne également des procédés de criblage de médicaments pour déterminer leur effet inhibiteur potentiel sur l'activation des plaquettes.