1,4-BIS-(AMINO-HYDROXYALKYLAMINO)-ANTHRAQUINONES FOR INHIBITING PROTEIN KINASE C

• Main Authors: JIANG, JACK, B, JOHNSON, MARY, GEORGE
• Format: Patent
• Language: English
• Published: 14.05.1992
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention provides novel substituted anthraquinones having formula (I), wherein R1? and R2? are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR3?R4?, Cl, Br, I, F, alkyl, aryl alkoxy, aroxy, COOR5?, or CONR6?R7?; R3?, R4?, R5?, R6?, and R7? are independently H, lower alkyl or aryl useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury. L'invention concerne de nouvelles anthraquinones substituées de la formule (I) dans laquelle R1 et R2 représentent indépendamment H, alkyle, aryle ou arylalkyle; m et n représentent indépendamment 1,2 ou 3; X représente H, OH, NR3R4, Cl, Br, I, F, alkyle, arylalcoxy, aroxy, COOR5, ou CONR6R7; R3, R4, R5, R6 et R7 représentent indépendamment H, alkyle ou aryle inférieur utilisés dans l'inhibition de la protéine kinase C ainsi que dans le traitement d'états relatifs à ou affectés par l'inhibition de la protéine kinase C, notamment de tumeurs cancéreuses, de maladies inflammatoires, de lésions de reperfusion et de dysfonctionnements cardiaques liés à des lésions de reperfusion.