USE OF PURINERGIC RECEPTOR AGONISTS AS ANTINEOPLASTIC AGENTS

• Main Authors: TREPEL, JANE, B, PIRNIA, FARZANEH, FANG, WEI-GANG, MYERS, CHARLES, E., JR
• Format: Patent
• Language: English
• Published: 31.10.1991
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The instant invention is directed to the use of a pharmaceutical composition containing an effective amount of adenosine or an adenosine analog or derivative as an agent useful in the treatment of hormone-independent cancers, such as prostate cancer. The invention is also directed to diagnostic uses of these compounds to determine effective treatment regimes for specific tumors, a process for screening for new, therapeutically useful analogs of these compounds, and the use of these compounds in facilitating the extraction of intracellular components. L'invention concerne l'emploi d'une composition pharmaceutique contenant une dose efficace d'adénosine ou d'un analogue ou d'un dérivé d'adénosine utilisé comme agent utile dans le traitement de cancers indépendant des hormones tels que le cancer de la prostate. L'invention concerne également les emplois diagnostiques de ces composés permettant de déterminer des schémas de traitement efficaces contre des tumeurs spécifiques, un procédé de tri de nouveaux analogues thérapeutiquement utiles de ces composés, ainsi que l'emploi de ces composés pour faciliter l'extraction de constituants intracellulaires.