THIOPYRANO[2,3-b]INDOLE DERIVATIVE

This invention relates to a thiopyrano[2,3-b] indole derivative represented by general formula (I) (wherein R?1 and R?2 are the same or different from each other and each represents a hydrogen atom or a lower alkyl group and two broken lines represent each a single bond or one of them represents a d...

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Main Authors KOIDE, TOKUO, YANAGISAWA, ISAO, MIYATA, KEIJI, MATSUHISA, AKIRA, OHTA, MITSUAKI, SUZUKI, TAKESHI
Format Patent
LanguageEnglish
Japanese
Published 19.09.1991
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to a thiopyrano[2,3-b] indole derivative represented by general formula (I) (wherein R?1 and R?2 are the same or different from each other and each represents a hydrogen atom or a lower alkyl group and two broken lines represent each a single bond or one of them represents a double bond), and pharmacologically acceptable salts thereof. These compounds have an excellent 5-HT3? antagonism. Un dérivé de thiopyrano[2,3-b]indole est représenté par la formule générale (I), dans laquelle R1 et R2 sont identiques ou différents et représentent chacun un atome d'hydrogène ou un groupe alkyle inférieur et les deux lignes hachurées représentent chacune une liaison simple ou une des deux lignes représente une liaison double. Ce dérivé et ses sels pharmacologiquement admissibles ont un excellent antagonisme au 5-HT3.
Bibliography:Application Number: WO1990JP00329