TRANS-6-(2-(2-(SUBSTITUTED-PHENYL)-2-(OR-4-)HETEROARYL-5-SUBSTITUTED-1H-PYRROL-1-YL)-ETHYL)TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONE INHIBITORS OF CHOLESTEROL BIOSYNTHESIS

Certain trans-6-[2-[2-(substituted-phenyl)-3- (or 4-)heteroaryl-5-substituted-1_H-pyrrol-1-yl]ethyl]tetrahydro-4-hydroxy -2_H-pyran-2-ones and the corresponding lactone-ring-opened acids are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are t...

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Bibliographic Details
Main Authors ROTH, BRUCE, DAVID, SLISKOVICAGO, ROBERT
Format Patent
LanguageEnglish
Published 01.12.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Certain trans-6-[2-[2-(substituted-phenyl)-3- (or 4-)heteroaryl-5-substituted-1_H-pyrrol-1-yl]ethyl]tetrahydro-4-hydroxy -2_H-pyran-2-ones and the corresponding lactone-ring-opened acids are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
Bibliography:Application Number: WO1987US03047