PYRIDINE DERIVATIVES

• Main Authors: TSURUDA MINEO, OE TAKANORI, GOTO KAZUHIRO, HISADOME MASAO
• Format: Patent
• Language: English; Japanese
• Published: 24.06.1982
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Pyridine derivatives represented by the following general formula$(4,)$ wherein R?1, R?2, R?3, and R?4, which may the same or different, each represents a hydrogen atom or a lower alkyl group, or R?1 and R?2, or R?3 and R?4, are taken together to form a hetero ring together with the adjacent nitrogen atom, A?1 and A?2, which may be the same or different, each represents an alkylene or hydroxy-substituted alkylene group, Y?1 and Y?2, which may be the same or different, each represents an oxygen or sulfur atom, and Z represents $(3,)$ or the pharmaceutically acceptable acid addition salts thereof. These compounds show pharmacological effects such as acceleration of leukocyte phagocytosis, acceleration of macrophage phagocytosis, acceleration of production of rosette forming cells of spleen, and depression of adjuvant arthritis, thus being useful as medicines. Derives de pyridine representes par la formule generale suivante: (FORMULE) ou R1, R2, R3 et R4, qui peuvent etre identiques ou differents, representent chacun un atome d'hydrogene ou un groupe alkyle inferieur, ou R1 et R2, ou R3 et R4, servent a former ensemble un hetero cycle en combinaison avec l'atome d'azote adjacent, A1 et A2, qui peuvent etre identiques ou differents, representent chacun un groupe alkylene ou un groupe alkylene substitue par un hydroxy, Y1 et Y2, qui peuvent etre identiques ou differents, representent chacun un atome d'oxygene ou de soufre, et Z represente (FORMULE) ou les sels acides d'addition pharmaceutiquement acceptables de ceux-ci. Ces composes presentent des effets pharmacologiques tels que l'acceleration de la phagocytose des leucocytes, l'acceleration de la phagocytose des macrophages, l'acceleration de la production des cellules de la rate formant des rosettes, et la reduction de l'arthrite adjuvente, ce qui les rend utile en tant que medicaments.