COMBINED USE OF ANTIBODY-DRUG CONJUGATE AND ANTI-EGFR ANTIBODY

• Main Authors: CHEN, Guoliang, SUN, Danni, ZHOU, Yuanfeng, XU, Min
• Format: Patent
• Language: Chinese; English; French
• Published: 14.08.2025
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to combined use of an antibody-drug conjugate and an anti-EGFR antibody or an antigen-binding fragment thereof. Specifically, the present invention provides a pharmaceutical combination comprising an antibody-drug conjugate or a pharmaceutically acceptable salt thereof, a metabolite thereof, or a solvate thereof as a single agent, an anti-EGFR antibody or an antigen-binding fragment thereof, and optionally a platinum-based drug. Further provided is use of the pharmaceutical combination of the present application in preparing a drug for treating a tumor in a subject. Further provided is a method for treating a tumor in a subject, comprising administering to the subject the pharmaceutical combination of the present application. La présente invention concerne l'utilisation combinée d'un conjugué anticorps-médicament et d'un anticorps anti-EGFR ou d'un fragment de liaison à l'antigène de celui-ci. La présente invention concerne, plus précisément, une combinaison pharmaceutique compre