NANOPARTICLES COMPRISING AMPHIPHILIC POLYMERS AND LIPIDS FOR THE TARGETED DELIVERY OF ANTIGENS

The present application relates to nanoparticles comprising (a) an amphiphilic polymer; (b) a first lipid comprising a polar head group and a non-polar tail group; and (c) a peptide comprising a T cell epitope. Also disclosed are populations of said nanoparticles, processes for manufacturing said na...

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Main Authors WALLNER, Gerhard, FANZUTTI, Marco, POHLNER, Johannes, SARKO, Dikran, SCHRÖTER, Christian, DIGIGOW, Reinaldo, MUNGALPARA, Disha, MESQUITA, Ligia Margarida Marques, SHAPOSHNYKOV, Artem, SELECI, Muharrem, VOCATURO, Anna-Lisa, KRZIKALLA, Daria
Format Patent
LanguageEnglish
French
Published 17.07.2025
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application relates to nanoparticles comprising (a) an amphiphilic polymer; (b) a first lipid comprising a polar head group and a non-polar tail group; and (c) a peptide comprising a T cell epitope. Also disclosed are populations of said nanoparticles, processes for manufacturing said nanoparticles, precursors for manufacturing said nanoparticles, pharmaceutical compositions of said nanoparticles, and methods of treating a disease or disorder comprising administering said nanoparticles to a subject. La présente demande concerne des nanoparticules comprenant (a) un polymère amphiphile ; (b) un premier lipide comprenant un groupe de tête polaire et un groupe de queue non polaire ; et (c) un peptide comprenant un épitope de lymphocyte T. Des populations desdites nanoparticules, des processus de fabrication desdites nanoparticules, des précurseurs pour la fabrication desdites nanoparticules, des compositions pharmaceutiques desdites nanoparticules et des méthodes de traitement d'une maladie ou d'un trouble comprenant l'administration desdites nanoparticules à un sujet sont également divulgués.
Bibliography:Application Number: WO2025EP50546