IONIZABLE LIPID COMPOUNDS, LIPID NANOPARTICLES (LNPS) COMPRISING THE SAME, AND METHODS OF USE THEREOF FOR CELL ENGINEERING

In one aspect, the present disclosure provides ionizable lipid compounds and lipid nanoparticles comprising the same. In further aspects, the present disclosure provides methods of in vivo and ex vivo cell engineering, engineered cells prepared according to the methods described herein, and methods...

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Bibliographic Details
Main Authors MUKALEL, Alvin, MITCHELL, Michael J, THATTE, Ajay
Format Patent
LanguageEnglish
French
Published 24.10.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:In one aspect, the present disclosure provides ionizable lipid compounds and lipid nanoparticles comprising the same. In further aspects, the present disclosure provides methods of in vivo and ex vivo cell engineering, engineered cells prepared according to the methods described herein, and methods of use thereof for treating, preventing, and/or ameliorating one or more diseases and/or disorders in a subject, including but not limited to autoimmune diseases and/or disorders and cancer. Selon un aspect, la présente divulgation concerne des composés lipidiques ionisables et des nanoparticules lipidiques les comprenant. Dans d'autres aspects, la présente divulgation concerne des procédés de génie cellulaire in vivo et ex vivo, des cellules modifiées préparées selon les procédés présentement décrits, ainsi que des méthodes d'utilisation de ceux-ci pour traiter, prévenir et/ou atténuer une ou plusieurs maladies et/ou un ou plusieurs troubles chez un sujet, comprenant, mais sans y être limités, des maladies et/ou des troubles auto-immuns et le cancer.
Bibliography:Application Number: WO2024US25109