SELECTIVE INHIBITORS OF ROCK2 PROTEIN KINASES AND USES THEREOF

The present invention relates to novel substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for...

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Main Authors LEE, Wongil, HWANG, So, YOUNG, Miyong, DIEBOLD, R, SEUNG, Sang-Ae, DASHNAMOORTHY, Ravi, GUPTA, Anu, DEVINE, William, KOH, Jong, LEE, Jaekyoo
Format Patent
LanguageEnglish
French
Published 24.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel substituted bicyclic derivatives that can selectively inhibit ROCK2 and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for preparing the derivatives and/or compositions, and methods for using the derivatives and/or compositions. La présente invention concerne de nouveaux dérivés bicycliques substitués qui peuvent inhiber sélectivement la phosphorylation médiée par ROCK2 et/ou Rho-kinase de phosphates à chaîne légère de myosine, des compositions comprenant les dérivés, des procédés de préparation des dérivés et/ou des compositions, et des procédés d'utilisation des dérivés et/ou des compositions.
Bibliography:Application Number: WO2024US19430