METHODS FOR TREATMENT OF AUTOIMMUNE DISEASES

Provided herein are methods of treating subjects having or suspected of having an autoimmune disease (e.g., systemic lupus erythematosus and/or lupus nephritis) with natural killer (NK) cells, and related compositions, uses, and articles of manufacture. In some aspects, the NK cells express a recomb...

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Main Authors BLAUS, Alison, LAZETIC, Alexandra, HORA, Sandeep, YU, Wendy, TRAGER, James, GIP, Phung, TOHMÉ, Mira, KOTHARI, Nishi, SHOOK, David, VEJIGA, Meriam
Format Patent
LanguageEnglish
French
Published 10.10.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:Provided herein are methods of treating subjects having or suspected of having an autoimmune disease (e.g., systemic lupus erythematosus and/or lupus nephritis) with natural killer (NK) cells, and related compositions, uses, and articles of manufacture. In some aspects, the NK cells express a recombinant receptor, such as a CD19-directed chimeric antigen receptor (CAR). L'invention concerne des méthodes de traitement de sujets atteints ou suspectés d'avoir une maladie auto-immune (par exemple, le lupus érythémateux systémique et/ou la néphropathie lupique) avec des cellules tueuses naturelles (NK), ainsi que des compositions, des utilisations, des articles manufacturés associés. Selon certains aspects, les cellules NK expriment un récepteur recombiné, tel qu'un récepteur antigénique chimérique (CAR) dirigé contre CD19.
Bibliography:Application Number: WO2024US23051