MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE

The present disclosure relates to pharmaceutical compounds of the Formula (I), (II), (III), (IV), or (V) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (...

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Bibliographic Details
Main Authors IYENGAR, Rajesh R, SCHMIDT, Darby R, LEE, Thomas Wai-Ho
Format Patent
LanguageEnglish
French
Published 10.10.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure relates to pharmaceutical compounds of the Formula (I), (II), (III), (IV), or (V) or a pharmaceutically acceptable salt or composition thereof. Also provided are methods of use of TRPML modulators for treating disorders, the modulators including compounds of the Formula (I), (II), (III), (IV), or (V). Such methods of use include treatment of ciliopathies. La présente invention concerne des composés pharmaceutiques de formule (I), (II), (III), (IV), ou (V) ou un sel pharmaceutiquement acceptable ou une composition de ceux-ci. L'invention concerne également des procédés d'utilisation de modulateurs de TRPML pour traiter des troubles, les modulateurs comprenant des composés de formule (I), (II), (III), (IV) ou (V). De tels procédés d'utilisation comprennent le traitement de ciliopathies.
Bibliography:Application Number: WO2024US22577