SUBSTITUTED INDAZOLE PROPIONIC ACID DERIVATIVE COMPOUNDS AND USES THEREOF AS AMPK ACTIVATORS

• Main Authors: CAMERON, Kimberly O'Keefe, LEE, Esther Cheng Yin, EBNER, David Christopher, TU, Meihua Mike, GERSTENBERGER, Brian Stephen, SMITH, Aaron Christopher, KUNG, Daniel Wei-Shung, FILIPSKI, Kevin James, O'BRIEN, Jessica Gloria Katherine, FERNANDO, Dilinie Prasadhini, HUH, Chan Woo, MATHIOWETZ, Alan Martin, BHATTACHARYA, Samit Kumar, CONN, Edward Lee, MEAR, Sarah Jane
• Format: Patent
• Language: English; French
• Published: 10.10.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to substituted indazole propionic acid derivatives of formula (I), pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof that can activate adenosine 5'-monophosphate- activated protein kinase (AMPK). The invention further relates to pharmaceutical compositions comprising AMPK-activating substituted indazole propionic acid derivatives of formula (I), pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof and at least one pharmaceutically acceptable excipient, and methods of treating a condition comprising administering AMPK-activating substituted indazole propionic acid derivatives of formula (I), pharmaceutically acceptable salts, tautomers, or pharmaceutically acceptable salts of the tautomers thereof. L'invention concerne des dérivés d'acide indazole propionique substitués de formule (I), des sels pharmaceutiquement acceptables, des tautomères ou des sels pharmaceutiquement acceptables de leurs tautomères qui peuvent activer la protéine kinase activée par l'adénosine 5'-monophosphate (AMPK). L'invention concerne en outre des compositions pharmaceutiques comprenant des dérivés d'acide indazole propionique substitués activant l'AMPK de formule (I), des sels pharmaceutiquement acceptables, des tautomères ou des sels pharmaceutiquement acceptables de leurs tautomères et au moins un excipient pharmaceutiquement acceptable, et des méthodes de traitement d'une affection comprenant l'administration des dérivés d'acide indazole propionique substitués activant l'AMPK de formule (I), des sels pharmaceutiquement acceptables, des tautomères ou des sels pharmaceutiquement acceptables de leurs tautomères.