NOVEL COMPOUND AS ENDOTHELIAL TO MESENCHYMAL TRANSITION (ENDMT) INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

• Main Authors: LEE, Yoon Jin, KIM, Ji Hee, KIM, Shin Ae, CHO, Jae Ho, LEE, Bong Yong, CHO, Young Kyoung, NAM, Jae Kyung
• Format: Patent
• Language: English; French; Korean
• Published: 26.09.2024
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention relates to a novel compound as an EndMT inhibitor and a pharmaceutical composition comprising same, and, more specifically, to a novel compound as an EndMT inhibitor and a pharmaceutical composition for treating pulmonary diseases, comprising same as an active ingredient. The compound according to the present invention exhibits excellent EndMT inhibitory activity, and thus can be effectively used for preventing and treating various pulmonary diseases associated with EndMT activity. La présente invention concerne un nouveau composé utilisé en tant qu'inhibiteur d'EndMT et une composition pharmaceutique le comprenant, et, plus particulièrement, un nouveau composé utilisé en tant qu'inhibiteur d'EndMT et une composition pharmaceutique pour le traitement de maladies pulmonaires, le comprenant en tant que principe actif. Le composé selon la présente invention présente une excellente activité inhibitrice de EndMT, et peut ainsi être efficacement utilisé pour prévenir et traiter diverses maladies pulmonaires associées à l'activité EndMT. 본 발명은 EndMT 억제제로서의 신규 화합물 및 이를 포함하는 약학적 조성물에 관한 것으로, 더 상세하게는 EndMT 억제제로서의 신규 화합물 및 이를 유효성분으로 포함하는 폐 질환 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 화합물은 우수한 EndMT 억제 활성을 나타내는바, EndMT 활성과 관련된 다양한 폐 질환의 예방 및 치료에 유용하게 사용될 수 있는 장점이 있다.