ROR1-TARGETING ANTIBODY, ANTIBODY-DRUG CONJUGATE COMPRISING SAME, PREPARATION METHOD THEREFOR, AND USE THEREOF

• Main Authors: LAI, Shoupeng, LING, Hong, ZHANG, Peng, WANG, Xin, HUANG, Xiao, KANG, Xiaoqiang, MENG, Tao, SHEN, Jingkang, MA, Lanping
• Format: Patent
• Language: Chinese; English; French
• Published: 26.09.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Provided are a ROR1-targeting antibody, an antibody-drug conjugate comprising same, a preparation method therefor, and a use thereof. The ROR1-targeting antibody or an antigen-binding fragment thereof has a heavy chain variable region, a light chain variable region, and a complementarity determining region (CDR). Additionally provided are an antibody-drug conjugate comprising the ROR1-targeting antibody or an antigen-binding fragment thereof, a preparation method therefor, and a use thereof. L'invention concerne un anticorps ciblant ROR1, un conjugué anticorps-médicament le comprenant, un procédé de préparation correspondant et une utilisation associée. L'anticorps ciblant ROR1 ou un fragment de liaison à l'antigène de celui-ci a une région variable de chaîne lourde, une région variable de chaîne légère et une région déterminant la complémentarité (CDR). L'invention concerne en outre un conjugué anticorps-médicament comprenant l'anticorps ciblant ROR1 ou un fragment de liaison à l'antigène de celui-ci, son pr