COMPOSITION FOR PREVENTING OR TREATING CEREBRAL INFARCTION

• Main Authors: JEONG, Han Seong, YU, Hee, JANG, Su Jeong, KIM, Eung Pil, JANG, Eun Jae
• Format: Patent
• Language: English; French; Korean
• Published: 19.09.2024
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention provides a pharmaceutical composition and health functional food for preventing or treating cerebral infarction, the composition comprising micro RNA-412-5P (miR-412-5P). The miR-382-5P is involved in nervous system development, neurotrophin signaling pathways, Hippo signaling pathways, axon guidance, and Wnt/PCP pathways. The composition according to the present invention has an excellent effect in reducing the extent or severity of cerebral infarction. La présente invention concerne une composition pharmaceutique et un aliment fonctionnel de santé pour prévenir ou traiter un infarctus cérébral, la composition comprenant du micro-ARN-412-5P (miR-412-5P). Le miR-382-5 P est impliqué dans le développement du système nerveux, les voies de signalisation de la neurotrophine, les voies de signalisation de l'Hippo, le guidage de l'axone et les voies Wnt/PCP. La composition selon la présente invention présente un excellent effet sur la réduction de l'étendue ou de la gravité de l'infarctus cérébral. 본 발명은 마이크로 RNA-412-5P(miR-412-5P)를 포함하는 뇌경색 예방 또는 치료용 약학 조성물 및 건강기능식품을 제공한다. 상기 miR-412-5P는 신경계 발달, 뉴로트로핀 신호 전달 경로, 히포 신호 전달 경로, 축삭 인도 및 Wnt/PCP pathway에 관여한다. 본 발명의 조성물은 뇌경색 범위 또는 정도를 줄이는데 우수한 효과를 가진다.