A PROCESS FOR THE PREPARATION OF CARPROFEN

The specification discloses a process for the preparation of Carprofen comprising converting diethyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-methylmalonate of Formula (II) to diethyl 2-(6-chloro-9H-carbazol-2-yl)-2-methylmalonate of Formula (III) in the presence of a copper salt and conve...

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Bibliographic Details
Main Authors SINGANAN, Ponnuchamy, KARRI, Phaneendrasai
Format Patent
LanguageEnglish
French
Published 15.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The specification discloses a process for the preparation of Carprofen comprising converting diethyl 2-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-2-yl)-2-methylmalonate of Formula (II) to diethyl 2-(6-chloro-9H-carbazol-2-yl)-2-methylmalonate of Formula (III) in the presence of a copper salt and converting the compound of Formula (III) to Carprofen. La présente invention concerne un procédé de préparation de carprofène comprenant la conversion de 2-(6-chloro-2,3,4,9-tétrahydro-1H-carbazol-2-yl)-2-méthylmalonate de diéthyle de formule (II) en diéthyl 2-(6-chloro-9H-carbazol-2-yl)-2-méthylmalonate de formule (III) en présence d'un sel de cuivre et la conversion du composé de formule (III) en carprofène.
Bibliography:Application Number: WO2024IB50327