COMBINATIONS OF DGK (DIACYLGLYCEROL KINASE) INHIBITORS AND IMMUNE CHECKPOINT INHIBITORS AND MODULATORS
The present invention covers combinations of at least two components, component A and component B, comprising component A consisting of one or more DGK (Diacylglycerol Kinase) inhibitors and component B consisting of one or more immune checkpoint modulators. Another aspect of the present invention c...
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Main Authors | , , , , , , , , , , , |
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Format | Patent |
Language | English French |
Published |
15.08.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention covers combinations of at least two components, component A and component B, comprising component A consisting of one or more DGK (Diacylglycerol Kinase) inhibitors and component B consisting of one or more immune checkpoint modulators. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly of a condition with dysregulated immune responses, particularly cancer, or a viral infection or another disorder associated with aberrant DGKα and/or DGKζ signaling.
La présente invention concerne des associations d'au moins deux composants, le composant A et le composant B, comprenant le composant A constitué d'un ou plusieurs inhibiteurs de DGK (diacylglycérol kinase) et le composant B constitué d'un ou plusieurs modulateurs de point de contrôle immunitaire. Un autre aspect de la présente invention concerne l'utilisation de telles associations telles que décrites dans la description pour la préparation d'un médicament pour le traitement ou la prophylaxie d'une maladie, en particulier d'une affection avec des réponses immunitaires dérégulées, en particulier le cancer, ou une infection virale ou un autre trouble associé à une signalisation aberrante de DGKα et/ou DGKζ. |
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Bibliography: | Application Number: WO2024EP52712 |