SPRK1 INHIBITORS AND METHODS OF USE

Provided herein are compounds having a structure of Formula (I) and pharmaceutically acceptable salts thereof which can act as modulators of serine/arginine-rich splicing factor protein kinase- 1 (SRPK1). Further disclosed herein are methods for treating cancer and vascular diseases and disorders. L...

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Bibliographic Details
Main Authors KUHN, Cyrille, LI, Lianhai
Format Patent
LanguageEnglish
French
Published 25.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds having a structure of Formula (I) and pharmaceutically acceptable salts thereof which can act as modulators of serine/arginine-rich splicing factor protein kinase- 1 (SRPK1). Further disclosed herein are methods for treating cancer and vascular diseases and disorders. L'invention concerne des composés ayant une structure de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, qui peuvent agir en tant que modulateurs de la protéine kinase 1 du facteur d'épissage riche en sérine/arginine (SRPK1). L'invention concerne en outre des méthodes de traitement du cancer et de maladies et de troubles vasculaires.
Bibliography:Application Number: WO2024US12097