USE OF 1-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-[3-(4-CYANOPHENOXY)PHENYL]UREA IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USED FOR PREVENTING AND/OR TREATING EYE DISEASES

• Main Authors: CHEN, Kuen-Feng, CHAO, Tzu-i
• Format: Patent
• Language: Chinese; English; French
• Published: 25.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided in the present invention is the use of 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea in the preparation of pharmaceutical compositions used for preventing and/or treating eye diseases. 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea inhibits angiogenesis in an oxygen-induced retinopathy model, reduces the total node area in the oxygen-induced retinopathy model, alleviates choroidal neovascularization in a laser-induced choroidal neovascularization model, relieves subretinal fibrosis, and reduces the quantities of mRNA and protein expression of collagen 1A1 and fibronectin, thereby achieving the effect of preventing and/or treating eye diseases. La présente invention concerne l'utilisation de 1-[4-chloro-3-(trifluorométhyl)phényl]-3-[3-(4-cyanophénoxy)phényl]urée dans la préparation de compositions pharmaceutiques utilisées pour prévenir et/ou traiter des maladies oculaires. La 1-[4-chloro-3-(trifluorométhyl)phényl]-3-[3-(4-cyanophénoxy)phényl]urée inh