INDUCIBLE CONSTRUCTS

The disclosure provides inducible constructs comprising transcription initiators and/or transcription regulators. These constructs may be used to drive expression of genes, in response to particular cell states (such as in the context of antigen stimulation). In some embodiments, the constructs are...

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Main Authors HAESELEER, Francoise J, HAMMER, Jared Louis, NG, Andrew Howen, KIRKPATRICK, Robin L, MOFFETT, Howell, CROWL, Ty, SAMPLE, Paul Joseph
Format Patent
LanguageEnglish
French
Published 18.07.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The disclosure provides inducible constructs comprising transcription initiators and/or transcription regulators. These constructs may be used to drive expression of genes, in response to particular cell states (such as in the context of antigen stimulation). In some embodiments, the constructs are incorporated as a part of regulatory circuits useful to control expression and regulation of cells expressing engineered receptors. La divulgation prévoit des constructions inductibles comprenant des initiateurs de transcription et/ou des régulateurs de transcription. Ces constructions peuvent être utilisées pour commander l'expression de gènes, en réponse à des états cellulaires particuliers (tels que dans le contexte de la stimulation d'antigène). Dans certains modes de réalisation, les constructions sont incorporées en tant que parties de circuits régulateurs utiles pour commander l'expression et la régulation de cellules exprimant des récepteurs modifiés.
Bibliography:Application Number: WO2024US10926