COMPOUNDS FOR FGFRS INHIBITORS

A compound having the following structure of Formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R5, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described. L'inventio...

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Main Authors BETTENDORF, Tanna, CHATTERJEE, Payal, FULTON, Jennifer, SMITH, Aaron Christopher, DAHLKE, Joshua, MALINKY, Cori A, SCAGGS, Toya D, RODRIGUEZ, Martha E, MEJIA, Macedonio J, ROBINSON, John E, FISCHER, John P, NEWHOUSE, Bradley J, CHICARELLI, Mark Joseph, FELL, Jay Bradford, VINE, Logan E, RIEGER, Robert A, JALLURI, Ravi Kumar, SALITURO, Leah J
Format Patent
LanguageEnglish
French
Published 18.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A compound having the following structure of Formula (I): (I) or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R5, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described. L'invention concerne un composé ayant la structure suivante de formule (I) : (I) ou un stéréoisomère, un sel ou un tautomère de celui-ci, formule dans laquelle R1, R2, R5, A, B, X, et Y sont tels que définis dans la description. L'invention concerne également une composition pharmaceutique comprenant les composés, et leur utilisation dans des procédés permettant de traiter des maladies.
Bibliography:Application Number: WO2024US10888