TRAC AND B2M MODULATING COMPOSITIONS AND METHODS

The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Heterologous gene modifying systems for disrupting the TRAC gene and/or the B2M gen...

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Bibliographic Details
Main Authors COTTA-RAMUSINO, Cecilia Giovanna Silvia, SCHIROLI, Giulia, MIR, Aamir, BOTHMER, Anne Helen
Format Patent
LanguageEnglish
French
Published 08.08.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Heterologous gene modifying systems for disrupting the TRAC gene and/or the B2M gene are described. L'invention concerne, par exemple, des compositions, des systèmes et des procédés de ciblage, d'édition, de modification ou de manipulation d'un génome de cellule hôte à un ou plusieurs emplacements dans une séquence d'ADN dans une cellule, un tissu ou un sujet. L'invention concerne également des systèmes de modification de gènes hétérologues destinés à perturber le gène TRAC et/ou le gène B2M.
Bibliography:Application Number: WO2024US10523