STABLE ROTIGOTINE TRANSDERMAL ADMINISTRATION KIT, AND PREPARATION METHOD THEREFOR AND USE THEREOF

• Main Author: TANG, Jiansheng
• Format: Patent
• Language: Chinese; English; French
• Published: 11.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided is a stable rotigotine transdermal administration kit, comprising a transdermal administration patch, wherein the transdermal administration patch comprises: 1) a backing layer; 2) a matrix layer, comprising rotigotine or a pharmaceutically acceptable salt thereof that are dispersed in the matrix layer in a non-crystalline state, a stabilizer for inhibiting drug crystallization, an antioxidant and a pressure-sensitive adhesive; and 3) a release layer. Further provided is the preparation method for and use of the kit. The transdermal administration kit maintains the content of related substances such as oxidized impurities in the transdermal patch at extremely low levels. L'invention concerne un kit d'administration transdermique de rotigotine stable, comprenant un timbre d'administration transdermique, le timbre d'administration transdermique comprenant : 1) une couche de support ; 2) une couche de matrice, comprenant de la rotigotine ou un sel pharmaceutiquement acceptable de celle-ci dispersé(e) da