ANTI-AAV2 MONOCLONAL ANTIBODY, AND PREPARATION METHOD AND USE THEREOF

• Main Authors: WANG, Fei, HE, Yuzhuo, DING, Lidan, FAN, Long
• Format: Patent
• Language: Chinese; English; French
• Published: 04.07.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention belongs to the field of virus detection and diagnosis, and relates to an anti-AAV2 monoclonal antibody, and a preparation method and use thereof. Provided are an anti-AAV2 rabbit monoclonal antibody, and an amino acid sequence of a heavy chain variable region and a light chain variable region of the AAV2-resistant rabbit monoclonal antibody. The anti-AAV2 rabbit monoclonal antibody provided by the invention can be specifically combined with the VLP of the AAV2, and can be used for detecting an AAV virus antigen. The anti-AAV2 monoclonal antibody provided by the invention provides an effective detection tool for the detection of AAV2 in the research and development process of a gene therapy vector and the detection of AAV2 in basic science research. L'invention appartient au domaine de la détection et du diagnostic de virus, et concerne un anticorps monoclonal anti-AAV2, son procédé de préparation et son utilisation. L'invention concerne un anticorps monoclonal de lapin anti-AAV2, et une séquence