AZEPINO[4,5-B]INDOLONE CGAS INHIBITORS

The present invention relates to novel cGAS inhibitor compounds, having a formula of (IIa) to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions such as immune-mediated diseases. La présente invention...

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Main Authors AHMED, Adel, GERNERT, Douglas L, CARSON, Cheryl Ann, TROMICZAK, Eric George, LUGAR, Charles W, FORTNER, Kevin Charles, ONOBUN, Emmanuel, CUMMING, Graham Robert, AGEJAS CHICHARRO, Francisco Javier, NAGARAJAN, Shanthi, MARTINEZ BROKAW, Christina, VARIN, Thibault Francois, GREEN, Steven J, CONNER, Scott Eugene, MARIMUTHU, Jothirajah
Format Patent
LanguageEnglish
French
Published 27.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to novel cGAS inhibitor compounds, having a formula of (IIa) to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions such as immune-mediated diseases. La présente invention concerne de nouveaux composés inhibiteurs de cGAS de formule (IIa), des compositions pharmaceutiques contenant les composés, ainsi que des méthodes d'utilisation des composés et des compositions pour traiter certaines affections pathologiques, telles que des maladies à médiation immunitaire.
Bibliography:Application Number: WO2023US85023