RECOMBINANT AAV CAPSIDS WITH CARDIAC- AND SKELETAL MUSCLE- SPECIFIC TARGETING MOTIFS AND USES THEREOF

Provided herein are compositions including muscle (cardiac and skeletal) cell-targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising Xn - non-RGD-n-mer - Xm. Compositions providing such conjugates, targeting pepti...

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Bibliographic Details
Main Authors LIAN, Sharon, MEGGERSEE, Rosemary, SIMS, Joshua Joyner, SIDRANE, Jenny G
Format Patent
LanguageEnglish
French
Published 20.06.2024
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Summary:Provided herein are compositions including muscle (cardiac and skeletal) cell-targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising Xn - non-RGD-n-mer - Xm. Compositions providing such conjugates, targeting peptides, or recombinant vectors having an engineered capsid or envelope protein are provided as are uses thereof. L'invention concerne des compositions comprenant des peptides ciblant les cellules musculaires (cardiaques et squelettiques) liés à ceux-ci ou insérés dans une protéine de ciblage d'un vecteur recombinant ayant au moins un peptide exogène comprenant Xn - non-RGD-n-mer - Xm. L'invention concerne également des compositions fournissant de tels conjugués, peptides de ciblage ou vecteurs recombinants ayant une capside ou une protéine d'enveloppe modifiée ainsi que leurs utilisations.
Bibliography:Application Number: WO2023US84198