RECOMBINANT AAV MUTANT VECTORS WITH CARDIAC AND SKELETAL MUSCLE-SPECIFIC TARGETING MOTIFS AND COMPOSITIONS CONTAINING SAME

Provided herein are compositions including muscle (cardiac and/or skeletal) cell-targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising Xn - RGD-n-mer - Xm. Compositions providing such conjugates, targeting peptid...

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Bibliographic Details
Main Authors WILSON, James M, MEGGERSEE, Rosemary, SIMS, Joshua Joyner, SIDRANE, Jenny A, HOFFMAN, Jacob
Format Patent
LanguageEnglish
French
Published 20.06.2024
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Summary:Provided herein are compositions including muscle (cardiac and/or skeletal) cell-targeting peptides linked thereto or inserted in a targeting protein of a recombinant vector having at least one exogenous peptide comprising Xn - RGD-n-mer - Xm. Compositions providing such conjugates, targeting peptides, or recombinant vectors having an engineered capsid or envelope protein are provided as are uses thereof. L'invention concerne des compositions comprenant des peptides de ciblage de cellules musculaires (cardiaques et/ou squelettiques) liés à ceux-ci ou insérés dans une protéine de ciblage d'un vecteur recombinant ayant au moins un peptide exogène comprenant Xn - RGD-n-mer - Xm. L'invention concerne des compositions fournissant de tels conjugués, des peptides de ciblage, ou des vecteurs recombinants ayant une capside modifiée ou une protéine d'enveloppe, ainsi que leurs utilisations.
Bibliography:Application Number: WO2023US84192