STEALTH LIPID NANOPARTICLE COMPOSITIONS FOR CELL TARGETING

The present disclosure provides stealth lipid nanoparticle (LNP) compositions engineered to target specific tissues or cell-types, e.g., T cells, B cells, natural killer cells, to genetically modify the cells with therapeutic nucleic acid encapsulated in the LNP. The present disclosure also provides...

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Bibliographic Details
Main Authors RAGHAV, Jimit, SAMAYOA, Phillip, OONTHONPAN, Lalita, SLUBOWSKI, Christian, STANTON, Matthew, GUPTA, Anshul, ZHANG, Sandy, PERNICIARO, Anthony, MARTIN, Constance, GALLAGHER, Nolan, SILVER, Nathaniel, ROSE, Douglas
Format Patent
LanguageEnglish
French
Published 06.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides stealth lipid nanoparticle (LNP) compositions engineered to target specific tissues or cell-types, e.g., T cells, B cells, natural killer cells, to genetically modify the cells with therapeutic nucleic acid encapsulated in the LNP. The present disclosure also provides compositions and methods of making the LNPs and treatment using the same. La présente divulgation propose des compositions de nanoparticules lipidiques furtives (LNP) modifiées pour cibler des tissus ou des types de cellules spécifiques, par exemple, des lymphocytes T, des lymphocytes B, des cellules tueuses naturelles, pour modifier génétiquement les cellules avec un acide nucléique thérapeutique encapsulé dans la LNP. La présente divulgation propose également des compositions et des procédés de fabrication des LNP et un traitement les utilisant.
Bibliography:Application Number: WO2023US82078