IONIZABLE LIPIDS AND LIPID NANOPARTICLE COMPOSITIONS FOR THE DELIVERY OF NUCLEIC ACIDS

Novel ionizable lipids are provided. Also provided are novel lipid nanoparticle compositions for the delivery of nucleic acid material to cells in vitro and in vivo with different and improved pharmacokinetic profiles as compared to what is typically observed in the art. Also provided are methods fo...

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Bibliographic Details
Main Authors SAGI, Amit, BURKE, Rob
Format Patent
LanguageEnglish
French
Published 23.05.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Novel ionizable lipids are provided. Also provided are novel lipid nanoparticle compositions for the delivery of nucleic acid material to cells in vitro and in vivo with different and improved pharmacokinetic profiles as compared to what is typically observed in the art. Also provided are methods for using the compositions in research and as therapeutics. L'invention concerne de nouveaux lipides ionisables. L'invention concerne également de nouvelles compositions de nanoparticules lipidiques pour l'administration de matériau d'acide nucléique à des cellules in vitro et in vivo avec des profils pharmacocinétiques différents et améliorés par rapport à ce qui est typiquement observé dans l'état de la technique. L'invention concerne en outre des méthodes d'utilisation des compositions en recherche et en tant qu'agents thérapeutiques.
Bibliography:Application Number: WO2023US79923