GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A PENTA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES

An insulin conjugate comprising or consisting of a penta-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide, such as glucose or alpha-met...

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Main Authors ZHU, Yuping, LIN, Songnian, MOYES, Christopher R, HUNTER, David N, HUO, Pei, PISSARNITSKI, Dmitri A, YAN, Lin
Format Patent
LanguageEnglish
French
Published 16.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An insulin conjugate comprising or consisting of a penta-valent sugar cluster is described. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide, such as glucose or alpha-methylmannose. L'invention concerne un conjugué d'insuline comprenant ou constitué d'un groupe de sucre pentavalent. Dans des aspects particuliers, le conjugué d'insuline affiche un profil pharmacocinétique (PK) et/ou pharmacodynamique (PD) qui réagit aux concentrations systémiques d'un saccharide tel que le glucose ou l'alpha-méthylmannose.
Bibliography:Application Number: WO2023US78774