BISPECIFIC ANTIBODY COMPOUNDS

Disclosed are new compounds comprising two antigen binding sites and a tetramerization site, where the antigen binding sites are selected among natural binding sites. The new compounds have improved manufacturability, stability and solubility compared with similar compounds based on scFv binding sit...

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Main Authors GILLBERG, Mette, LISBY, Steen, LIEBENBERG, Nico, LUND-HANSEN, Torben, CHRISTENSEN, Søren, KJELLEV, Stine Louise Reedtz, WIBERG, Finn Christoph
Format Patent
LanguageEnglish
French
Published 16.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are new compounds comprising two antigen binding sites and a tetramerization site, where the antigen binding sites are selected among natural binding sites. The new compounds have improved manufacturability, stability and solubility compared with similar compounds based on scFv binding sites, making the disclosed compound much better candidates for active ingredients in pharmaceutical compositions. L'invention divulgue de nouveaux composés comprenant deux sites de liaison à l'antigène et un site de tétramérisation, les sites de liaison à l'antigène étant sélectionnés parmi des sites de liaison naturels. Les nouveaux composés ont une aptitude à la fabrication, une stabilité et une solubilité améliorées par rapport à des composés similaires basés sur des sites de liaison scFv, faisant des composés divulgués de bien meilleurs candidats pour des ingrédients actifs dans des compositions pharmaceutiques.
Bibliography:Application Number: WO2023DK50269