ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE

• Main Authors: DAWADI, Surendra, MURHADE, Ganesh, LEE, Kyunga, CHAN, Warren Christopher, SAINZ, Marcos Adrian, POTOTSCHNIG, Gerit Maria, KOLAKOWSKI, Gabrielle R, WRIGHT, Nathan A, SCAGGS, Latoya Denise, JETTE, Carina, LONG, Katelyn, CHEN, Shuai, WANG, Xia, ANDERSON, Erin, WANG, Hua-Yu, IRVIN, Thomas, KUMAR, Manoj, MAYNE, Christopher Glenn, SALIB, Mariam Nader, PICADO VALENZUELA, Alfredo
• Format: Patent
• Language: English; French
• Published: 31.10.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I): (I) or pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein. The disclosure also relates to methods of making and using compounds of Formula (I) or pharmaceutically acceptable salts thereof. L'invention concerne des composés de formule (I) en tant qu'inhibiteurs chroménone allostériques de phosphoinositide 3-kinase (PI3K) utiles dans le traitement de maladies ou de troubles associés à la modulation de PI3K, formule (I) : (I) ou des sels pharmaceutiquement acceptables de ceux-ci, où R1, R2, R3, R4, R5, R6, R7, et R8 sont tels que définis dans la description. L'invention concerne également des procédés de fabrication et d'utilisation de composés de formule (I) ou de sels pharmaceutiquement acceptables de ceux-ci.