IMIDAZOLE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS

Disclosed herein are imidazole compounds and compositions useful in the treatment of a disease or disorder associated with sodium channel mediated activity, such as epilepsy, having the structures of Formulas (I)-(XV) wherein the R groups, A, and L are as defined in the detailed description. Methods...

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Bibliographic Details
Main Author RICHARDSON, Thomas E
Format Patent
LanguageEnglish
French
Published 10.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed herein are imidazole compounds and compositions useful in the treatment of a disease or disorder associated with sodium channel mediated activity, such as epilepsy, having the structures of Formulas (I)-(XV) wherein the R groups, A, and L are as defined in the detailed description. Methods of inhibition of disease or disorder associated with sodium channel mediated activity in a subject are also provided. L'invention concerne des composés imidazoles et des compositions utiles dans le traitement d'une maladie ou d'un trouble associé à une activité médiée par un canal sodique, comme l'épilepsie, ayant les structures de formules (I)-(XV) dans lesquelles les groupes R, A et L sont tels que définis dans la description détaillée. L'invention concerne également des procédés d'inhibition d'une maladie ou d'un trouble associé à une activité médiée par un canal sodique chez un sujet.
Bibliography:Application Number: WO2023US36385