NLRP3 INFLAMMASOME INHIBITOR AND USE THEREOF

• Main Authors: LI, Lin, WU, Frank
• Format: Patent
• Language: Chinese; English; French
• Published: 10.05.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention belongs to the technical field of medicine, relates to an NLRP3 inflammasome inhibitor and a use thereof, and specifically relates to a compound represented by a general formula (A') or a pharmaceutically acceptable salt, stereoisomer and deuterated product thereof, the definition of each group being as defined in the description. Studies have shown that the compound represented by general formula (A') or the pharmaceutically acceptable salt, stereoisomer and deuterated product thereof have high biological activity against an NLRP3 inflammasome, and have important clinical development value for the treatment of NLRP3-related diseases. Y-W-R3 (A') La présente invention appartient au domaine technique de la médecine, concerne un inhibiteur de l'inflammasome NLRP3 et son utilisation, et concerne en particulier un composé représenté par la formule générale (A') ou un sel pharmaceutiquement acceptable, un stéréoisomère et un produit deutéré de celui-ci, la définition de chaque groupe étant te