USE OF ANTI-ANGIOPOIETIN-LIKE PROTEIN 4 ANTIBODY IN PREPARATION OF DRUG FOR INHIBITING EXPRESSION OF INFLAMMATORY FACTOR

• Main Authors: ZHANG, Peng, CHENG, Wenxiang, LI, Liang, KE, Liqing
• Format: Patent
• Language: Chinese; English; French
• Published: 10.05.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided is use of an anti-angiopoietin-like protein 4 antibody in the preparation of a drug for inhibiting the expression of an inflammatory factor. By constructing a mouse animal model of collagen-induced arthritis (CIA) to stimulate the disease state of RA, and using different doses of anti-ANGPTL4 antibodies to perform therapeutic intervention on the CIA model, it is found that the treatment with the anti-ANGPTL4 antibody can significantly reduce the expression of cytokine IL-6, can effectively improve bone destruction of the ankle joint caused by RA, and can relieve local synovial hyperplasia and inflammatory cell infiltration in the joint, thereby proving that the anti-ANGPTL4 antibody can be used in the preparation of a drug for treating inflammatory diseases of bones and joints. Est fournie l'utilisation d'un anticorps anti-protéine 4 de type anti-angiopoïétine dans la préparation d'un médicament pour inhiber l'expression d'un facteur inflammatoire. En construisant un modèle animal de souris de l'arth