PRODUCTION METHOD FOR ETHYL 8-CHLOROOCTANOATE

Disclosed is a production method for ethyl 8-chlorooctanoate in the field of medicine or pesticide manufacturing. A dual catalyst containing potassium bromide or sodium bromide and polyethylene glycol is used, and an alkylation reaction is carried out by corresponding 1,6-dichlorohexane and diethyl...

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Bibliographic Details
Main Authors QU, Jun, WU, Hongxiang, XUE, Honglan, GAO, Dehua, HU, Zhong, ZHANG, Pengcheng
Format Patent
LanguageChinese
English
French
Published 18.04.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a production method for ethyl 8-chlorooctanoate in the field of medicine or pesticide manufacturing. A dual catalyst containing potassium bromide or sodium bromide and polyethylene glycol is used, and an alkylation reaction is carried out by corresponding 1,6-dichlorohexane and diethyl malonate in the presence of potassium carbonate. After the reaction ends, a crude product of diethyl 6-chlorohexyl malonate is obtained by distillation, and then under the catalysis of a sulfonic acid, a one-pot method is used to complete hydrolysis and decarboxylation, distillation under reduced pressure to remove water, and ethanol esterification, and finally rectification is performed to obtain high-purity ethyl 8-chlorooctanoate, which can meet the needs of customers. The present method simplifies production operations, shortens unit operation time, reduces labor intensity, and improves product quality. L'invention concerne un procédé de production de 8-chlorooctanoate d'éthyle, relevant du domaine de la médeci
Bibliography:Application Number: WO2022CN143964