HSD17B13 INHIBITORS AND/OR DEGRADERS

Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH. L'invention concerne des composés de formule I, le...

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Main Authors ZHANG, Liying, LEE, Jisun, DUTRA, Jason Kenneth, ZHANG, Lei, WRIGHT, Ann Sorrentino, HOU, Xinjun, ADAMS, Jan Antoinette Cusi Romero, GARNSEY, Michelle Renee, NASON II, Deane Milford, WANG, Yang, EDMONDS, David James, O, NEILL, RANKIC, Danica Antonia, BECHLE, Bruce Michael
Format Patent
LanguageEnglish
French
Published 11.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH. L'invention concerne des composés de formule I, les variables étant définies dans la description, leur utilisation en tant qu'inhibiteurs et/ou agents de dégradation de HSD17B13, des compositions pharmaceutiques contenant de tels composés et leur utilisation pour traiter, par exemple, la NAFLD et la NASH.
Bibliography:Application Number: WO2023IB59988