METHODS OF IMPROVING PRODUCTION OF MORPHINAN ALKALOIDS AND DERIVATIVES

Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone...

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Bibliographic Details
Main Authors PAYNE, James T, KOZINA, Amy M, ESTRADA, Rodrigo A, HAWKINS, Kristy M, SMOLKE, Christina D
Format Patent
LanguageEnglish
French
Published 04.04.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. L'invention concerne des procédés qui peuvent être utilisés pour la synthèse d'alcaloïdes de benzylisoquinoline ("BIA") tels que le morphinane alcaloïde. Les procédés décrits peuvent être utilisés pour produire de la thébaïne, de l'oripavine, de la codéine, de la morphine, de l'oxycodone, de l'hydrocodone, de l'oxymorphone, de l'hydromorphone, de la naltrexone, de la naloxone, de l'hydroxycodéinone, de la néopinone et/ou de la buprénorphine.
Bibliography:Application Number: WO2023US75653