DIRECTED IN VIVO AFFINITY MATURATION OF ANTIBODIES

• Main Authors: FARZAN, Michael R, HE, Wenhui, OU, Tianling, YIN, Yiming
• Format: Patent
• Language: English; French
• Published: 06.06.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The disclosure provides methods for promoting affinity maturation, and in particular in vivo affinity maturation, of antibodies. The disclosure also provides a system of affinity maturation of an antibody as well as compositions comprising antibodies generated from methods described herein and polynucleotides encoding such systems. La divulgation concerne des procédés pour favoriser la maturation d'affinité, et en particulier la maturation d'affinité in vivo , d'anticorps. La divulgation concerne également un système de maturation d'affinité d'un anticorps ainsi que des compositions comprenant des anticorps générés à partir de procédés décrits ici et des polynucléotides codant pour de tels systèmes.