DIRECTED IN VIVO AFFINITY MATURATION OF ANTIBODIES

The disclosure provides methods for promoting affinity maturation, and in particular in vivo affinity maturation, of antibodies. The disclosure also provides a system of affinity maturation of an antibody as well as compositions comprising antibodies generated from methods described herein and polyn...

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Bibliographic Details
Main Authors FARZAN, Michael R, HE, Wenhui, OU, Tianling, YIN, Yiming
Format Patent
LanguageEnglish
French
Published 06.06.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The disclosure provides methods for promoting affinity maturation, and in particular in vivo affinity maturation, of antibodies. The disclosure also provides a system of affinity maturation of an antibody as well as compositions comprising antibodies generated from methods described herein and polynucleotides encoding such systems. La divulgation concerne des procédés pour favoriser la maturation d'affinité, et en particulier la maturation d'affinité in vivo , d'anticorps. La divulgation concerne également un système de maturation d'affinité d'un anticorps ainsi que des compositions comprenant des anticorps générés à partir de procédés décrits ici et des polynucléotides codant pour de tels systèmes.
Bibliography:Application Number: WO2023US75636