HETEROCYCLES AS MODULATORS OF NSD ACTIVITY

Disclosed herein are amino bicyclic nitrogen heterocyclic ring system compounds which inhibit nuclear receptor-binding SET domain proteins (NSD's), such as 6-amino-9H-purin-9-yl, imidazo[2,1-f][1,2,4]triazin-4-amine, 4-amino pyrazolo[1,5-a][1,3,5]triazin-8-yl ring systems, and in particular the...

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Bibliographic Details
Main Authors HAMILTON, Matthew, RAMASWAMY, Suyambu Kesava Vijayan, JONES, Philip, LE, Kang, SOTH, Michael
Format Patent
LanguageEnglish
French
Published 16.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed herein are amino bicyclic nitrogen heterocyclic ring system compounds which inhibit nuclear receptor-binding SET domain proteins (NSD's), such as 6-amino-9H-purin-9-yl, imidazo[2,1-f][1,2,4]triazin-4-amine, 4-amino pyrazolo[1,5-a][1,3,5]triazin-8-yl ring systems, and in particular the 8-amino imidazo[1,2-a]pyrazin-3-yl system, as well as their pharmaceutical formulations, and their methods of utilization in the treatment of NSD-mediated diseases, such as certain cancers. L'invention concerne des composés qui inhibent des protéines de domaine SET de liaison au récepteur nucléaire (NSD), des formulations pharmaceutiques et des méthodes de traitement de maladies médiées par NSD, telles que certains cancers.
Bibliography:Application Number: WO2023US74671