CITRATE SALT OF CYCLIN-DEPENDENT KINASE (CDK4/6) INHIBITOR, CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF

• Main Authors: ZHU, Shuang, WANG, Kexin, ZHU, Qiaoyou, HUANG, Wenshu, JIN, Meixia, PENG, Yuhui, LIU, Jiuzhi, YU, Jiangtian
• Format: Patent
• Language: Chinese; English; French
• Published: 04.04.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a citrate salt of a compound of formula (I). The present invention also relates to a crystal form A, a crystal form B, a crystal form C, and a crystal form D of the citrate salt of the compound of formula (I). The present invention also relates to a pharmaceutical composition comprising at least one of the citrate salt of the compound of formula (I) of the present invention, and the crystal form A, the crystal form B, the crystal form C, and the crystal form D of the citrate salt of the compound of formula (I) of the present invention. The present invention also relates to use of the citrate salt of the present invention, the crystal form A, the crystal form B, the crystal form C, and the crystal form D of the citrate salt of the present invention, and the pharmaceutical composition of the present invention in the preparation of a drug for treating, preventing or ameliorating abnormal cell proliferation. The present invention also relates to use of the citrate salt of the pres