THIAZOLE DERIVATIVES AS TAU AGGREGATION INHIBITORS

The present invention provides compounds of general formula (I): or pharmaceuticaly acceptable salts, solvates or hydrates thereof, wherein RN is independently -H or - Me; RX is independently C1-4 alkyl, optionaly substituted with halo or hydroxy; -NHRN1, wherein RN1 is C1-4 alkyl; or C5-10 heteroar...

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Main Authors STOREY, John Mervyn David, MAZANETZ, Michael Philip, WISCHIK, Claude Michel, KEMP, Steven John, SERPELL, Louise Charlotte, PALLIYIL SOMAN, Soumya, SIMPSON, Michael
Format Patent
LanguageEnglish
French
Published 28.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of general formula (I): or pharmaceuticaly acceptable salts, solvates or hydrates thereof, wherein RN is independently -H or - Me; RX is independently C1-4 alkyl, optionaly substituted with halo or hydroxy; -NHRN1, wherein RN1 is C1-4 alkyl; or C5-10 heteroaryl; RY is independently: C5-10 heteroaryl, optionaly substituted with methyl, halo or phenyl; or neopentyl. The compounds are of use as tau aggregation inhibitors (TAIs). La présente invention concerne des composés de formule générale (I), ou des sels, solvates ou hydrates pharmaceutiquement acceptables de ceux-ci, RN représentant indépendamment -H ou -Me; RX représentant indépendamment alkyle en C1-4, éventuellement substitué par halo ou hydroxy; -NHRN1, RN1 représentant alkyle en C1-4 ; ou hétéroaryle en C5-10; RY représentant indépendamment : hétéroaryle en C5-10, éventuellement substitué par méthyle, halo ou phényle; ou néopentyle. Les composés sont utiles en tant qu'inhibiteurs d'agrégation de tau (TAI).
Bibliography:Application Number: WO2023EP74788