SYSTEMS AND METHODS FOR TRANSPOSING CARGO NUCLEOTIDE SEQUENCES

The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to...

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Bibliographic Details
Main Authors GOLTSMAN, Daniela S.A, THOMAS, Brian C, BROWN, Christopher
Format Patent
LanguageEnglish
French
Published 14.03.2024
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Summary:The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a transposase, and the transposase, wherein said transposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site. La présente divulgation concerne des systèmes et des procédés pour la transposition d'une séquence nucléotidique de chargement à un site d'acide nucléique cible. Ces systèmes et procédés peuvent comprendre un premier acide nucléique double brin comprenant la séquence nucléotidique de chargement, la séquence nucléotidique de chargement étant conçue pour interagir avec une transposase, ladite transposase étant conçue pour transposer la séquence nucléotidique de chargement vers le site d'acide nucléique cible.
Bibliography:Application Number: WO2023US73796