NANO-COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF

• Main Authors: SHI, Kai, BI, Hongshu
• Format: Patent
• Language: Chinese; English; French
• Published: 29.02.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NANOTECHNOLOGY; ORGANIC CHEMISTRY; PEPTIDES; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The present disclosure relates to a nano-composition, a preparation method therefor, and use thereof. The nano-composition is formed by self-assembly of an oligopeptide containing a tryptophan dipeptide motif and cisplatin. The general formula of the oligopeptide is Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-W-W-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12, wherein W is tryptophan, and Xaa1-Xaa12 are each independently absent or each independently represent an arbitrary amino acid residue. The nano-composition features mild preparation conditions, simple operation, environmental friendliness, etc., thus being suitable for industrial production and enabling efficient loading of medicaments. The nano-composition can be used for the preparation of anti-tumor medicaments. La présente divulgation concerne une nanocomposition, son procédé de préparation et son utilisation. La nanocomposition est formée par auto-assemblage d'un oligopeptide contenant un motif dipeptidique de tryptophane et du cisplatine. La formule générale de l'oligopeptid