BISPECIFIC ANTIBODIES AND CONSTRUCTS FOR LYSOSOMAL TARGETING DEGRADATION AND METHODS OF USE THEREOF

Provided herein are antigen-binding proteins (ABPs) that selectively bind to M6PR and its isoforms and homologs, and compositions comprising the ABPs. Also provided herein are bispecific antigen-binding proteins (ABPs) that selectively bind to internalizing receptors, and a soluble target molecule o...

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Bibliographic Details
Main Authors LINDHOUT, Darrin Anthony, SHURTLEFF, Matthew James, YAU, Richard Gar Wai
Format Patent
LanguageEnglish
French
Published 23.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are antigen-binding proteins (ABPs) that selectively bind to M6PR and its isoforms and homologs, and compositions comprising the ABPs. Also provided herein are bispecific antigen-binding proteins (ABPs) that selectively bind to internalizing receptors, and a soluble target molecule or cell surface target molecule and its isoforms and homologs, and compositions comprising the ABPs. L'invention concerne des protéines de liaison à l'antigène (ABPs) qui se lient sélectivement à M6PR et ses isoformes et homologues, et des compositions comprenant les ABPs. L'invention concerne également des protéines bispécifiques de liaison à l'antigène (ABPs) qui se lient sélectivement à des récepteurs d'internalisation, et une molécule cible soluble ou une molécule cible de surface cellulaire et ses isoformes et homologues, et des compositions comprenant les ABPs.
Bibliography:Application Number: WO2023US30120