ADJUVANTED IMMUNOGENIC COMPOSITION AGAINST NEISSERIA MENINGITIDIS B

The disclosure relates to an immunogenic composition comprising a combination of Neisseria meningitidis serogroup B antigens, said combination comprising at least one factor H binding protein (fHBP) A and at least one factor H binding protein (fHBP) B, and an aluminum hydroxyphosphate (AlPO4) adjuva...

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Bibliographic Details
Main Authors RAHMAN, Nausheen, DARMONT, Anne-Gaëlle, AUSAR, Salvador Fernando, BALHARA, Vinod
Format Patent
LanguageEnglish
French
Published 08.02.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The disclosure relates to an immunogenic composition comprising a combination of Neisseria meningitidis serogroup B antigens, said combination comprising at least one factor H binding protein (fHBP) A and at least one factor H binding protein (fHBP) B, and an aluminum hydroxyphosphate (AlPO4) adjuvant, the AlPO4 adjuvant being selected as having a point of zero charge (PZC) below 5. La divulgation concerne une composition immunogène comprenant une combinaison d'antigènes de sérogroupe B de Neisseria meningitidis, ladite combinaison comprenant au moins une protéine de liaison au facteur H (fHBP) A et au moins une protéine de liaison au facteur H (fHBP) B, et un adjuvant hydroxyphosphate d'aluminium (AlPO4), l'adjuvant AlPO4 étant choisi comme ayant un point de charge zéro (PZC) inférieur à 5.
Bibliography:Application Number: WO2023US71474